OzemPIC cuts the desire for alcohol, can be disrupted by addiction treatment
- For the first time, a random experiment showed the truce of the intense desire for alcohol.
- The researchers say that this opens the door to search for isolated alcohol to adopt alcohol.
- Scientists are racing to determine the path of the brain concerned to cancel the secure of new addiction treatments.
A major new study on weight loss medications that constitute a new idea for addiction treatment: small doses of OzemPic can help people reduce drinking and smoking.
This week, psychiatry jama Published The results of a small but important experience have shown a similar effect on the desire for alcohol. For two months, 48 people with alcohol abuse disorder are given either a small weekly snacking, and the active ingredient in OzemPIC and Wegovy, or fake. Those who received the drug drink less and report fewer desires.
Federally funded the first random experiment-the golden standard of clinical research-in view of the craving for Ozambi and alcohol, is after years of Ozemping user reports that they feel less alcohol.
There was a bonus discovery, too. Cigarette smokers, who received a dose of semules, reduced their daily cigarette consumption than those who got the placebo.
The researchers say the results open a completely new world of drug developers. Can we manufacture a new dose smaller than the GLP-1 drugs that people can use to break the habits?
“I can absolutely see the exact treasury to embody.
“This may be a good thing if someone does this and success in the dry January, and you may return to drinking in February, but it reduces Bings and goes to something more sustainable for daily life.”
We still have major questions about this. More experiments are needed with different doses, longer than time, on more people.
However, scientists wander around this experiment, what we know about the system of rewards in our brain, and the possibility of drug development.
Here are some of the reasons for conspiracies, according to three researchers:
Dopamine vacuum cleaner
We still have a lot to learn how GLP-1 medications work on the brain, although alcohol studies offer some clues.
It is tempting that, since Smaglutide can help people reduce calories and sugar, it similarly reduces the “appetite” of alcohol. It is not so simple.
For example, animal studies have shown that the GLP-1 drugs reduce the desire for alcohol in mice, but also slowing the desire to repair in mice that were yearning for cocaine, which is calorie-free.
“We know a little about it,” Fink Jinsen told the internal business program. “We really don’t know how medications reach there. There are areas to regulate appetite and know that they reach these areas. But how they reach the rest of the brain, we don’t really understand.”
One theory is that the GLP-1 drugs reduce dopamine’s rush in the brain, and a feeling of pleasure caused by some behaviors such as dessert or expensive whispering.
It does this by strengthening a specific type of protein through complex cellular processes. Scientists are still working.
“It is a vacuum cleaner for dopamine and mainly absorbs dopamine,” Stanod told Business Insider. “Rewards such as drinking, gambling, sex, share a mechanism to increase the amount of dopamine in your mind. Excess dopamine cleaning reduces incentives for these behaviors.”
The race to explain this brain effect – to open a completely new drug market
There is a high possibility of this field of research. Everyone who can explain exactly what GLP-1 for the brain will be the toast of the drug industry. Treatments for alcohol abuse can be developed – and much more.
“Addiction in general, also functional addiction like gaming addiction,” Dr. Marco Lahantinvo, a researcher of Easten Venland University, who specializes in how drugs affect the brain.
Therefore, the race is on. Lähteenvuo said the central dopamine organization is the “most rooted for”, but there is no shortage of research teams looking for other interpretations.
It is difficult to assess the safety of such treatments without understanding how drugs work like working in the brain in the brain.
“The question is, does the GLP-1 stimulate it do so all the time or when dopamine is excessive?” Stanod said. “If this is all the time, this may be a problem because we need these dopamine visits to reinforce these wonderful things like embracing your children, listening to music, chocolate cakes. We don’t want to defend nothing.”
To date, the research supports the theory that the GLP-1 works on excessive dopamine levels. One of the main results of the last study is that the participants did not stop drinking completely, or even often, but they were less likely to drink heavily and less than drinks in the session when they did so.
Why really (really!) You need to consult a doctor before trying this
In the future, GLP-1 can be a tool for people to manage their drinking.
The difficult part is safety.
The researchers told BI that the stigma on addiction could frighten investors from the development of the GLP-1 of drug abuse. OzemPIC has other profitable and attractive applications that companies can develop medicines from the next generation, such as preventing heart attacks or kidney disease.
“It may take it easily three, four years or longer if it is not interested or if the data is not positive as we hope it is,” Fink Jensen said.
People-and do it-go out of the designation from the GLP-1 weight loss, and find OzemPic (technically a drug for diabetes) from gray web sites in the market. Fink-Jensen said it is a risky step, even under supervision, because we do not yet understand how this drug is used for addiction.
“We really suggest that people avoid describing these vehicles now and are waiting for more powerful data.”
- Morgan McFall-Johnsen contributed to the reports.